After inflicting a severe wound on Tsunade, Orochimaru asks why she is willing to give her life to protect Naruto. Shaking at the sight of her own blood, Tsunade replies that it’s to save Konoha, since Naruto will be the Hokage one day. Orochimaru is dismissive of what he hears, as in his opinion the title of Hokage is for fools who put their lives on the line. Remembering her own words that she told Naruto a week earlier, Tsunade informs Orochimaru that it is now her turn to become one of those fools and risk her life, thus accepting the position of Fifth Hokage. Orochimaru delivers the final blow and then tries to kill Naruto, but Tsunade manages to cover him with her body. Overcoming her fear of blood, she counterattacks, pushing Orochimaru back. Breaking the seal and applying Divine Regeneration, Tsunade heals all her wounds. Resistance builds up and the sannin performs the most powerful invocation.